IL33 in rheumatoid arthritis: potential contribution to pathogenesis

Pathogenesis of Rheumatoid Arthritis

[Pathogenesis of rheumatoid arthritis].

Rheumatoid arthritis (RA) is an autoimmune systemic disease that primarily affects joints. Etiology and the pathogenesis of RA are complex, involving many types of cells, among others macrophages, T and B cells, fibro- blasts, chondrocytes and dendritic cells. Despite well documented role of many genes and epigenetic modifications in the development and evolution of the disease, in most RA pati...

Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritis

INTRODUCTION Interleukin (IL)-33 is a proinflammatory cytokine contributing to the pathogenesis of rheumatoid arthritis (RA). The gene encoding IL-33 may serve as a genetic factor and be associated with the risk of RA. To investigate the potential association between IL33 and RA, we performed a case-control study based on Chinese Han population. METHODS A three-stage case-control study was pe...

Contribution of inherited factors to rheumatoid arthritis.

A total of 231 sibships of the same sex (186 female, 45 male), in which the proband had classical or definite rheumatoid arthritis (RA) have been selected from rheumatology clinics. Each sibship member was questioned about symptomatic joints, which were then examined. Hospital records, radiographs, and rheumatoid factor measurements allowed each sibling to be classified as having classical, def...

The pathogenesis of rheumatoid arthritis.

From the College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom (I.B.M.); and the Department of Internal Medicine 3, University of Erlangen–Nuremberg, Erlangen, Germany (G.S.). Address reprint requests to Dr. McInnes at the College of Medical, Veterinary, and Life Sciences, University of Glasgow, Level 4, Sir Graeme Davis Bldg., 120 University Pl., Gla...